CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates
Abstract Background CD4-independence has been taken as a sign of a more open envelope structure that is more accessible to neutralizing antibodies and may confer altered cell tropism.In the present study, we analyzed SIVsm isolates for CD4-independent use of CCR5, mode of CCR5-use and macrophage tropism.The isolates have been collected sequentially